RAF Typhoon FGR4s have operated alongside French warplanes in a coordinated attack against an underground arms cache in Syrian territory employed by the Islamic State group (IS), per a report from the UK's MoD.
The facility, located using intelligence, was believed to be containing munitions and bombs, the statement said, and was situated in hills just to the north of the ancient city of Palmyra in central Syria.
"The RAF jets utilized precision-guided Paveway IV munitions to target a number of entry passages providing entry to the depot... initial indications suggest the strike was effective," officials stated.
There was no indication of any civilian casualties in the attack late on Saturday and every plane involved made a safe return, the MoD added.
The British jets were backed up by a Voyager tanker plane.
IS - also known as Daesh - established jihadist rule over large swathes of Iraq and Syria prior to its 2019 collapse.
"This action demonstrates British leadership, and determination to stand shoulder to shoulder with our partners, to stamp out any re-emergence of IS and their dangerous and violent ideologies in the region," the British Defence Secretary John Healey remarked.
RAF aircraft have carried out patrols over Syrian airspace to "forestall any attempted comeback" of the group after its defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I extend gratitude to the personnel of the UK armed forces who took part in this mission for their professionalism and their courage," he said. "Including them were numerous British personnel deployed over the holidays. This mission, to eliminate dangerous terrorists who endanger our safety, demonstrates how our armed forces are always on standby, continuously, ensuring Britain's security within its borders and strong abroad."
Last December, the US military carried out what it called a "massive strike" targeting Islamic State objectives in Syria, following an attack killed two American soldiers and a civilian linguist in the Palmyra area.
The UN estimates IS still boasts between 5,000 and 7,000 fighters in Iraq and Syria.